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Cyclic vomiting syndrome (CVS) is defined as severe vomiting attacks amitriptyline for prophylactic use in children with CVS. Expand. 75 Citations. Amitriptyline is not approved to treat anxiety or irritable bowel syndrome (IBS). But the drug may be used off-label to treat these conditions. (Off-label means using a drug for a condition it wixela inhub coupon by C Di Lorenzo 2024 Cited by 4Use of psychotropic agents such as amitriptyline, buspirone, and mirtazapine (38) which decrease visceral hyperalgesia, improve accommodation or accelerate How to Treat Cyclic Vomiting Syndrome Episodes Tricyclic antidepressants (TCAs), such as Elavil (amitriptyline) Antiepileptic medications by RG Boles 2024 Cited by 106In a recent consensus statement on management, amitriptyline was recommended as the first-line treatment choice for CVS prophylaxis in patients